Search results for "Oxygen delivery"
showing 3 items of 3 documents
Evaluation of Cardiac Volumetric and Functional Parameters
2012
The milestone definition of “Cardiac Function” has to be attributed to William Harvey, the discoverer of the circulation, who in 1628 stated: “The movement of the blood is constantly in a circle, and is brought about by the beat of the heart” [1, 2]. From a modern point of view, the main function of the heart is the delivery of oxygen to metabolizing tissues. Since oxygen delivery is dependent on (1) the oxygen-carrying capacity of blood, (2) the flow output from the heart, and (3) regional distribution of flow, then the heart is nowadays regarded as a pump with the function of supplying flow in blood vessels [2].
Validation of brain extracellular glycerol as an indicator of cellular membrane damage due to free radical activity after traumatic brain injury.
2008
Following severe traumatic brain injury (TBI), increasing oxygen delivery to the brain has been advocated as a useful strategy to reverse mitochondrial dysfunction and improve neurological outcome. However, this might also promote overproduction of free radicals, responsible for lipid peroxidation and hence brain cell damage. Therefore, a method for monitoring this potential adverse effect in humans is desirable. Glycerol, an end product of phospholipid breakdown, easily detectable in the human brain by means of microdialysis, might represent a reliable indicator of free radical-induced cell membrane damage. Brain microdialysates were collected from 24 adult male Sprague-Dawley rats over a …
Muscle Oxygen Delivery in the Forearm and in the Vastus Lateralis Muscles in Response to Resistance Exercise: A Comparison Between Nepalese Porters a…
2020
Altitude ascending represents an intriguing experimental model reproducing physiological and pathophysiological conditions sharing hypoxemia as the denominator. The aim of the present study was to investigate fractional oxygen extraction and blood dynamics in response to hypobaric hypoxia and to acute resistance exercises, taking into account several factors including different ethnic origin and muscle groups. As part of the “Kanchenjunga Exploration & Physiology” project, six Italian trekkers and six Nepalese porters took part in a high altitude trek in the Himalayas. The measurements were carried out at low (1,450 m) and high altitude (HA; 4,780 m). Near-infrared spectroscopy (NIRS)-d…